Recombinant Human BMPR1A protein (rFc Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg2704

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Validation Data Gallery

• 

  Purity of Recombinant Human BMPR1A was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Human BMPR1A protein Gln24-Arg152 (Accession# P36894) with a rabbit IgG Fc tag at the C-terminus.
• GeneID: 657
• Accession: P36894
• PredictedSize: 40.2 kDa
• SDS-PAGE: 40-50 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

BMPR1A (Bone morphogenetic protein receptor type-1A) is called ACVRLK3, ALK3, and SKR5. BMPR1A is an essential receptor for BMP signaling. BMPR1A is necessary for chondrogenesis and osteogenesis. BMPR1A is a cell surface marker of human SuSCs.

References:

1. Junjun Jing. et al. (2015). Vitam Horm. 99:273-291.
2. Tanja Mang. et al.(2020). J Cell Sci. 133(16):jcs246934.
3. Takamitsu Maruyama. et al. (2021). Sci Transl Med. 13(583):eabb4416.