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HSPD1(also known as HSP60) belongs to the chaperonin family and acts as a chaperone essential for protein folding. HSP60 is a widely expressed protein and has been connected with many aspects of cell functions including gene expression regulation, DNA replication, signal transduction, differentiation, apoptosis, and cellular senescence or immortalisation. Recently it has been reported that HSP60 was significantly up-regulated in squamous cell lung cancer.