Recombinant Human JAM3 protein (rFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg6611
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human JAM3 protein Val32-Asn241 (Accession# Q9BX67-1) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 83700 |
| Accession | Q9BX67-1 |
| PredictedSize | 49.9 kDa |
| SDS-PAGE | 52-62 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Junctional adhesion molecule 3 (JAM3) is a type I transmembrane glycoprotein containing two Ig-like domains, which is expressed in various tissues and plays a crucial role in cell junctions, cell polarity, and motility. It has been proposed that JAM3 participates in leukocyte-platelet interactions, as well as angiogenesis and brain development.
References:
1. De Rose, Domenico Umberto et al. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology vol. 42,11 (2021): 4759-4765. 2. Ebnet, Klaus. Physiological reviews vol. 97,4 (2017): 1529-1554. 3. Akawi, Nadia A et al. Human mutation vol. 34,3 (2013): 498-505.