Recombinant Human KLK10 protein (rFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg3132
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <1.0 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human KLK10 protein Ala31-Asn276 (Accession# O43240) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 5655 |
| Accession | O43240 |
| PredictedSize | 52.6 kDa |
| SDS-PAGE | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Kallikrein 10 (KLK10) is a member of the human tissue kallikrein family of secreted serine proteases. Kallikrein 10 was first identified through subtractive hybridization between normal and radiation-transformed mammary epithelial cells. Kallikrein 10 is expressed in the glandular epithelium and is found in multiple organs, including the kidneys, gastrointestinal tract, peripheral nerves, and specific neuroendocrine organs. Kallikrein 10 has primarily been investigated in the context of breast cancer.
References:
1. Borgoño, Carla A, and Eleftherios P Diamandis. Nature reviews. Cancer vol. 4,11 (2004): 876-90. 2. Kioulafa, M et al. Annals of oncology : official journal of the European Society for Medical Oncology vol. 20,6 (2009): 1020-5. 3. Luo, Yi-Chao et al. Biochemical and biophysical research communications vol. 689 (2023): 149217.