Recombinant Human MATN3 protein (rFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg3136
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human MATN3 protein Asp29-Arg486 (Accession# O15232) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 4148 |
| Accession | O15232 |
| PredictedSize | 75.4 kDa |
| SDS-PAGE | 68-75 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Matrilin-3 (MATN3) is linked to the development of many types of cartilage, and part of the Matrilin family, which includes MATN1, MATN2, MATN3, and MATN4, a family of filamentous-forming adapter oligomeric extracellular proteins that are linked to the formation of cartilage and bone, as well as maintaining homeostasis after development. It is considered an extracellular matrix protein that functions as an adapter protein where the MATN3 subunit can form both homo-tetramers and hetero-oligomers with subunits from MATN1 which is the cartilage matrix protein. This restricted tissue has been strongly expressed in growing skeletal tissue as well as cartilage and bone.
References:
1. Wang, Yi-Chun et al. International journal of molecular medicine vol. 36,6 (2015): 1648-56. 2. Muttigi, Manjunatha S et al. International journal of molecular sciences vol. 17,4 (2016): 590. 3. Pullig, O et al. Osteoarthritis and cartilage vol. 10,4 (2002): 253-63.