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Recombinant Human MCSF protein (His tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

His tag

Activity

not tested

Cat no : Eg1018

Validation Data Gallery

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <1.0 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human MCSF protein Glu33-Arg255 (Accession# P09603-1) with a His tag at the C-terminus.
GeneID 1435
Accession P09603-1
PredictedSize 26.2 kDa
SDS-PAGE
Formulation Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

M-CSF, also called colony-stimulating factor-1 or CSF-1), is a haematopoietic growth factor, which controls survival, proliferation, differentiation and function of mononuclear phagocytes. It also plays a role in bone metabolism, fertility, pregnancy and inflammatory processes. M-CSF may be expressed on the surface of the cell as a membrane-spanning glycoprotein or secreted into circumstance. M-CSF was identified as an 84-kDa homodimeric glycoprotein found in healthy human urine, and is present in the peripheral blood and urine. M-CSF serum levels were elevated in pre-transplant haemodialysis patients, so it might be a specific marker of Kidney Allograft Rejection.

References:

1. Pollard, J W et al. Nature vol. 330,6147 (1987): 484-6.
2. Witt, B R, and J W Pollard. Fertility and sterility vol. 68,2 (1997): 259-64.
3. Popova, Anna et al. Immunobiology vol. 216,1-2 (2011): 164-72.
4. Motoyoshi, K. International journal of hematology vol. 67,2 (1998): 109-22.
5. Motoyoshi, K et al. Blood vol. 52,5 (1978): 1012-20.
6. Le Meur, Yannick et al. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association vol. 19,7 (2004): 1862-5.