Recombinant Human NPTXR protein (rFc Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg3109

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Validation Data Gallery

• 

  Purity of Recombinant Human NPTXR was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Human NPTXR protein Ala24-Ala500 (Accession# P15144) with a rabbit IgG Fc tag at the C-terminus
• GeneID: 23467
• Accession: O95502
• PredictedSize: 76.5 kDa
• SDS-PAGE: 65-80 kDa & 85-100 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

NPTXR, or neuronal pentraxin receptor, is a gene in humans that encodes a protein with a significant role in the nervous system. NPTXR is a synaptic proteins involved in the regulation of physiological processes of memory and other cognitive functions (PMID: 31415236, PMID: 27332958). Decreased CSF levels of NPTXR may be applied as biomarkers of early synaptic dysfunction in AD (PMID: 26136856).

References:

1. Lim B. et al. (2019). Clin Chem Lab Med. 57(12):1875-1881. 
2. Lista S. et al. (2017). Expert Rev Neurother. 17(1):47-57. 
3. Kvartsberg H. et al. Alzheimers Res Ther. 7(1):40.