Recombinant Human PGLYRP1 protein (rFc Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg3122

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Validation Data Gallery

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <1.0 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Human PGLYRP1 protein Gln22-Pro196 (Accession# O75594) with a rabbit IgG Fc tag at the C-terminus.
• GeneID: 8993
• Accession: O75594
• PredictedSize: 45.0 kDa
• Formulation: Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Peptidoglycan recognition protein 1 (PGLYRP1, also known as PGRP-S) belongs to a family of evolutionarily conserved innate immunity proteins, which in mammals also include PGLYRP2, PGLYRP3, and PGLYRP4. PGLYRP1 is highly expressed in polymorphonuclear leukocytes and to a lower extent in many non-immune cells. It recognizes bacterial peptidoglycan and functions in antibacterial immunity and inflammation. PGLYRP1 has been identified as a ligand for TREM-1.

References:

1. Guan, Rongjin, and Roy A Mariuzza.  Trends in microbiology vol. 15,3 (2007): 127-34.
2. Dziarski, Roman, and Dipika Gupta. Innate immunity vol. 16,3 (2010): 168-74.
3. Read, Christine B et al. Journal of immunology (Baltimore, Md. : 1950) vol. 194,4 (2015): 1417-21.