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Recombinant Human SLAM/CD150 protein (His Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

His Tag

Activity

not tested

Cat no : Eg1702

Validation Data Gallery

  • Purity of Recombinant Human SLAM was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human SLAM was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human SLAM protein Ala21-Pro237 (Accession# Q13291-1) with a His tag at the C-terminus.
GeneID 6504
Accession Q13291-1
PredictedSize 25.4 kDa
SDS-PAGE 38-50 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Signaling lymphocytic activation molecule (SLAM, also known as SLAMF1 or CD150) is a glycoprotein found on the surface of T, B, natural killer, and dendritic cells. The extracellular domain of CD150 serves as a receptor for the measles virus, and CD150 acts as a co-activator on T and B cells (PMID: 11486275). SLAM is constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation (PMID: 7617038). SLAM is involved in T cell stimulation and cytokine production, and may play an important role in the regulation of immune responses to pathogens (PMID: 30366106).

References:

1. Wang N. et al. (2001). Immunogenetics. 53(5):382-394.
2. Cocks BG. et al. (1995). Nature. 376(6537):260-263.
3. Yigit B. et al. (2019). Clin Immunol. 204:3-13.