Recombinant Human Transthyretin protein (His tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

His tag

Activity

not tested

Cat no : Eg0931



Product Information

Purity >90 %, SDS-PAGE
Endotoxin <1.0 EU/μg protein, LAL method
Activity
Not tested
Expression HEK293-derived Human Transthyretin protein Gly21-Glu147 (Accession# P02766) with a His tag at the C-terminus.
GeneID 7276
Accession P02766
PredictedSize 14.8 kDa
SDS-PAGE
Formulation Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Transthyretin (TTR) is a plasma transport protein for thyroxine and retinol, through the association with retinol-binding protein. It is a homotetrameric protein synthesized mainly in liver, choroid plexus, retinal pigment epithelium, and pancreas.Within the CNS, TTR is the only known protein synthesized solely by the choroid plexus. Mutant and wildtype TTR give rise to various forms of amyloid deposition (amyloidosis). Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR),hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) and carpal tunnel syndrome type 1 (CTS1).

References:

1. Iwasaki, Takeshi et al. Neuropathology: official journal of the Japanese Society of Neuropathology vol. 31,6 (2011): 632-8. 2. Sousa, João Carlos et al. Neurobiology of aging vol. 28,5 (2007): 713-8.