Product Information
17511-1-PBS targets ICMT in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide Predict reactive species |
| Full Name | isoprenylcysteine carboxyl methyltransferase |
| Calculated Molecular Weight | 32 kDa |
| Observed Molecular Weight | 32-34 kDa |
| GenBank Accession Number | NM_012405 |
| Gene Symbol | ICMT |
| Gene ID (NCBI) | 23463 |
| RRID | AB_2293346 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | O60725 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Isoprenylcysteine carboxylmethyltransferase (ICMT), also known as PCCMT, is a multi-spanning endoplasmic reticulum integral membrane protein conserved among eukaryotic organisms. Methylation by ICMT is important for partitioning of CAAX proteins into lipid membranes as this modification neutralizes the negative charge on the carboxylate and increases the hydrophobicity of the modified protein (PMID: 25059662). Homozygous gene knockout of PPMT interferes with localization of K-Ras to the plasma membrane in mammalian cells and leads to the death of mouse embryos during gestation (PMID: 12141948).
