Anti-Human IL-18R1/CD218a Rabbit Recombinant Antibody, PBS Only

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  FC experiment of human peripheral blood leukocytes using 98150-2-RR (same clone as 98150-2-PBS)

  1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human IL-18R1/CD218a Rabbit Recombinant Antibody (98150-2-RR, Clone:241673D3) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) and PE-conjugated Goat Anti-Rabbit IgG. Cells were co-stained with CoraLite® Plus 647 Anti-Human NCAM1/CD56. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98150-2-PBS in a different storage buffer formulation.

• 

  FC experiment of human peripheral blood leukocytes using 98150-2-RR (same clone as 98150-2-PBS)

  1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human IL-18R1/CD218a Rabbit Recombinant Antibody (98150-2-RR, Clone: 241673D3) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9)(blue), and PE-conjugated Goat Anti-Rabbit IgG. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98150-2-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98150-2-RR

  Biolayer interferometry (BLl) kinetic assays of 98150-2-RR against Human IL-18R1/CD218a were performed. The affinity constant is 0.915 nM.

IL-18R1/CD218a Uni-rAb^TM Recombinant Antibody for FC

Cat No. 98150-2-PBS

Clone No.241673D3

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

IL18R1, 241673D3, CD218 antigen-like family member A, CD218a, EC:3.2.2.6

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Product Information

98150-2-PBS targets IL-18R1/CD218a in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Recombinant protein
• Full Name: interleukin 18 receptor 1
• Calculated Molecular Weight: 541 aa, 62 kDa
• GenBank Accession Number: BC093975
• Gene Symbol: IL18R1
• Gene ID (NCBI): 8809
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: Q13478
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

IL-18R1 (CD218a) is a component of the interleukin-18 receptor (IL-18R) complex, which is critical for the signaling of IL-18, a pro-inflammatory cytokine. This receptor complex, consisting of IL-18R1 and the IL-18 receptor accessory protein (IL-18RAP), belongs to the immunoglobulin-like family of interleukin-1 receptors (PMID: 35461924). IL-18R1 plays a significant role in inducing the production of interferon-gamma (IFN-γ) and other inflammatory cytokines, contributing to innate and adaptive immune responses (PMID: 2550053). It is also suggested to play a role in hypertension and chronic kidney disease, where the IL-18/IL-18R1 signaling axis may have diagnostic and therapeutic potential (PMID: 35461924).