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  • Flow cytometry (FC) experiment of human peripheral blood leukocytes using Anti-Human IL-18R1/CD218a Rabbit Recombinant Antib (98150-2-RR)

    FC experiment of human peripheral blood leukocytes using 98150-2-RR

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human IL-18R1/CD218a Rabbit Recombinant Antibody (98150-2-RR, Clone:241673D3) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) and PE-conjugated Goat Anti-Rabbit IgG. Cells were co-stained with CoraLite® Plus 647 Anti-Human NCAM1/CD56. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

  • Flow cytometry (FC) experiment of human peripheral blood leukocytes using Anti-Human IL-18R1/CD218a Rabbit Recombinant Antib (98150-2-RR)

    FC experiment of human peripheral blood leukocytes using 98150-2-RR

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human IL-18R1/CD218a Rabbit Recombinant Antibody (98150-2-RR, Clone: 241673D3) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9)(blue), and PE-conjugated Goat Anti-Rabbit IgG. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

  • Affinity and Kinetic Characterization of 98150-2-RR

    Affinity and Kinetic Characterization of 98150-2-RR

    Biolayer interferometry (BLl) kinetic assays of 98150-2-RR against Human IL-18R1/CD218a were performed. The affinity constant is 0.915 nM.

Anti-Human IL-18R1/CD218a Rabbit Recombinant Antibody

IL-18R1/CD218a Uni-rAbTM Recombinant Antibody for FC
Cat No. 98150-2-RR
Clone No.241673D3

Review Product

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

IL18R1, 241673D3, CD218 antigen-like family member A, CD218a, EC:3.2.2.6

Formulation:  PBS and Azide
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

- +

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Tested Applications

Positive FC detected inhuman peripheral blood leukocytes

Recommended dilution

ApplicationDilution
Flow Cytometry (FC)FC : 0.25 ug per 10^6 cells in 100 μl suspension
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

98150-2-RR targets IL-18R1/CD218a in FC applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Recombinant protein Predict reactive species
Full Name interleukin 18 receptor 1
Calculated Molecular Weight 541 aa, 62 kDa
GenBank Accession NumberBC093975
Gene Symbol IL18R1
Gene ID (NCBI) 8809
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDQ13478
Storage Buffer PBS with 0.09% sodium azide, pH 7.3.
Storage ConditionsStore at 2 - 8°C. Stable for one year after shipment.

Background Information

IL-18R1 (CD218a) is a component of the interleukin-18 receptor (IL-18R) complex, which is critical for the signaling of IL-18, a pro-inflammatory cytokine. This receptor complex, consisting of IL-18R1 and the IL-18 receptor accessory protein (IL-18RAP), belongs to the immunoglobulin-like family of interleukin-1 receptors (PMID: 35461924). IL-18R1 plays a significant role in inducing the production of interferon-gamma (IFN-γ) and other inflammatory cytokines, contributing to innate and adaptive immune responses (PMID: 2550053). It is also suggested to play a role in hypertension and chronic kidney disease, where the IL-18/IL-18R1 signaling axis may have diagnostic and therapeutic potential (PMID: 35461924).

Protocols

Product Specific Protocols
FC protocol for IL-18R1/CD218a antibody 98150-2-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols