INPP5E Antibody 12 Publications

Rabbit Polyclonal| Catalog number: 17797-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 54 μg/150 μl

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Species specificity:
human, mouse, rat, zebrafish

Positive WB detected in:
SH-SY5Y cells, HEK-293 cells, mouse brain tissue, mouse testis tissue

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human testis tissue, human brain tissue, human heart tissue, human kidney tissue, human ovary tissue, human placenta tissue, human spleen tissue, human testis tissue

Positive IF detected in:
hTERT-RPE1 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
inositol polyphosphate-5-phosphatase, 72 kDa

Calculated molecular weight:
644aa,70 kDa

Observed molecular weight:
64-66 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
INPP5E

Synonyms
INPP5E, PPI5PIV
Background

INPP5E(72 kDa inositol polyphosphate 5-phosphatase) converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2.In mouse, highest protein expression was in brain, heart, and testis, with lower expression in thymus and lung, and very little expression in kidney, spleen, and liver(PMID:10764818). Defects in INPP5E are the cause of Joubert syndrome type 1 (JBTS1) and mental retardation-truncal obesity-retinal dystrophy-micropenis (MORMS)(PMID:19668215). It has 2 isoforms with the molecular mass of 66 kDa and 70 kDa.


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