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  • KD/KO Validated

INVS Polyclonal antibody

INVS Polyclonal Antibody for WB, IF, IHC, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat





Cat no : 10585-1-AP


INV, inversin, INVS, KIAA0573, Nephrocystin 2

Tested Applications

Positive WB detected inMCF-7 cells, K-562 cells, L02 cells, SH-SY5Y cells, mouse skeletal muscle tissue, HepG2 cells, Raji cells, Jurkat cells
Positive IHC detected inhuman breast cancer tissue, human hepatocirrhosis tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inHela cells, hTERT-RPE1 cells

Recommended dilution

Western Blot (WB)WB : 1:200-1:1000
Immunohistochemistry (IHC)IHC : 1:20-1:200
Immunofluorescence (IF)IF : 1:10-1:100
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

10585-1-AP targets INVS in WB, IF, FC, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen INVS fusion protein Ag0934
Full Name inversin
Calculated Molecular Weight 118 kDa, 100 kDa
Observed Molecular Weight 100-110 kDa
GenBank Accession NumberBC006370
Gene Symbol INVS
Gene ID (NCBI) 27130
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

INVS, short for inversin, plays a role in primary cilia function and involvement in the cell cycle. It is required for normal renal development and establishment of the left-right axis. INVS may be involved in Wnt signaling pathways by acting as a molecular switch between different them. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. This antibody is a rabbit polyclonal antibody raised against part of the N-terminus of human INVS.


Product Specific Protocols
WB protocol for INVS antibody 10585-1-APDownload protocol
IHC protocol for INVS antibody 10585-1-APDownload protocol
IF protocol for INVS antibody 10585-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols




Cell type-specific regulation of ciliary transition zone assembly in vertebrates.

Authors - Antonia Wiegering
  • KO Validated

Proc Natl Acad Sci U S A

A complement factor H homolog, heparan sulfation, and syndecan maintain inversin compartment boundaries in C. elegans cilia.

Authors - Natalie Acker


PCP protein inversin regulates testis function through changes in cytoskeletal organization of actin and microtubules.

Authors - Linxi Li
  • KD Validated

Virchows Arch

Afferent arteriolopathy and glomerular collapse but not segmental sclerosis induce tubular atrophy in old spontaneously hypertensive rats.

Authors - Leh Sabine S

Am J Med Genet A

Early presentation of cystic kidneys in a family with a homozygous INVS mutation.

Authors - Machteld M Oud

JCI Insight

Cilia proteins are biomarkers of altered flow in the vasculature.

Authors - Ankan Gupta