|Positive WB detected in||human spleen tissue, THP-1 cells, HL-60 cells, U-937 cells|
|Positive IHC detected in||human tonsillitis tissue, human lung cancer tissue, human breast cancer tissue, human appendicitis tissue, human liver cancer tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:500-1:2000|
|Immunohistochemistry (IHC)||IHC : 1:800-1:3200|
|Sample-dependent, check data in validation data gallery|
The immunogen of 60258-1-Ig is CD11c/Integrin Alpha X Fusion Protein expressed in E. coli.
|Cited Reactivity||human, pig|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||CD11c/Integrin Alpha X fusion protein Ag11350|
|Full Name||integrin, alpha X (complement component 3 receptor 4 subunit)|
|Calculated molecular weight||1169 aa, 129 kDa|
|Observed molecular weight||145 kDa|
|GenBank accession number||BC038237|
|Gene ID (NCBI)||3687|
|Purification Method||Protein A purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits. CD11c/Integrin alpha X is a 145-150 kDa type I transmembrane glycoprotein present on a variety of cells, including monocytes/macrophages, granulocytes, NK cells and dendritic cells. Integrin alpha X/beta 2 acts a receptor for fibrinogen and is important in monocyte adhesion and chemotaxis.
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