LGR5 Polyclonal antibody

LGR5 Polyclonal Antibody for IHC,ELISA

Host / Isotype

Rabbit / IgG


human and More (1)





Cat no : 21833-1-AP


FEX, G protein coupled receptor 49, G protein coupled receptor 67, GPR49, GPR67, GRP49, HG38, LGR5

Tested Applications

Positive IHC detected inhuman small intestine tissue, human colon tissue, human colon cancer tissue, human liver cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

Immunohistochemistry (IHC)IHC : 1:100-1:400
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

The immunogen of 21833-1-AP is LGR5 Fusion Protein expressed in E. coli.

Tested Reactivity human
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen LGR5 fusion protein Ag16389
Full Name leucine-rich repeat-containing G protein-coupled receptor 5
Calculated Molecular Weight 907 aa, 100 kDa
GenBank Accession NumberBC096324
Gene Symbol LGR5
Gene ID (NCBI) 8549
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

LGR5, also named as GPR49, GPR67 and HG38, belongs to the G-protein coupled receptor 1 family. It is an orphan receptor. LGR5 is a stem cell marker of the intestinal epithelium and the hair follicule. It is a target gene of Wnt signaling.




LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma.

Authors - Gabriella Cunha Vieira

Inflamm Bowel Dis

Overexpression of Cancer-Associated Stem Cell Gene OLFM4 in the Colonic Epithelium of Patients With Primary Sclerosing Cholangitis.

Authors - Mastura Neyazi

J Dermatol Sci

REGγ regulates hair cycle by activating Lgr5 positive hair follicle stem cells.

Authors - Xiao Gao

Tumour Biol

Correlation of Musashi-1, Lgr5, and pEGFR expressions in human small intestinal adenocarcinomas.

Authors - Yan Wang

Oncol Lett

Detection of circulating colorectal cancer cells by a custom microfluid system before and after endoscopic metallic stent placement.

Authors - Rei Ishibashi

Oncol Lett

Expression and clinical significance of SALL4 and LGR5 in patients with lung cancer.

Authors - Ajay Kumar Gautam