MACROD1 Recombinant antibody, PBS Only

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  WB analysis using 84398-3-RR (same clone as 84398-3-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84398-3-RR (MACROD1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84398-3-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84398-3-RR

  Biolayer interferometry (BLl) kinetic assays of 84398-3-RR against Human MACROD1 were performed. The affinity constant is 11.1 nM.

MACROD1 Uni-rAb^TM Recombinant Antibody for WB, Indirect ELISA

Cat No. 84398-3-PBS

Clone No.241506C1

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

EC:3.2.2.-, EC:3.1.1.106, ADP-ribose glycohydrolase MACROD1, 241506C1, [Protein ADP-ribosylglutamate] hydrolase MACROD1

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Product Information

84398-3-PBS targets MACROD1 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: MACROD1 fusion protein Ag34080
• Full Name: MACRO domain containing 1
• Calculated Molecular Weight: 325 aa, 36 kDa
• Observed Molecular Weight: 28 kDa
• GenBank Accession Number: BC008316
• Gene Symbol: MACROD1
• Gene ID (NCBI): 28992
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: Q9BQ69
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

MACRO domain containing 1 (Macrod1) is also named as LRP16. Macrod1 is an ADP-ribosylhydrolase 1 that is highly enriched in mitochondria, participating in the pathogenesis of cardiovascular diseases (PMID: 38459256). MacroD1 was recruited to the sites of DNA damage via recognition of ADP-ribosylation at DNA lesions (PMID: 32683309). MacroD1 is highly expressed in human and mouse skeletal muscle (PMID: 29410655). Macrod1 may play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation (PMID: 17893710, PMID: 17914104). Macrod1 could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells (PMID: 17893710).