MCL1 Antibody 5 Publications

Mouse Monoclonal| Catalog number: 66026-1-Ig |CloneNo.: 1E3C2

Featured Product KD/KO validated

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Freight/Packing

Con: 181 μg/150 μl

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Species specificity:
human

Positive WB detected in:
Jurkat cells, HeLa cells, A431 cells, Raji cells

Positive IHC detected in:
human breast cancer tissue

Positive IF detected in:
MCF-7 cells, Hela cells

Recommended dilution:
WB : 1:2500-1:10000
IHC : 1:250-1:1000
IF : 1:10-1:100

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2b

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
myeloid cell leukemia sequence 1 (BCL2-related)

Calculated molecular weight:
350aa,37 kDa

Observed molecular weight:
37 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MCL1

Synonyms
EAT, Mcl 1, Mcl 1l, Mcl 1s Delta TM, MCL1, mcl1/EAT, MCL1L, MCL1S, TM
Background

MCL-1 is an anti-apoptotic member of the Bcl-2 family originally isolated from the ML-1 human myeloid leukemia cell line. Similar to BCL2 and BCL2L1, MCL1 can interact with BAX and/or BAK1 to inhibit mitochondria-mediated apoptosis. Mcl-1 is critical for the proliferation and survival of myeloma cells in vitro, and overexpression of Mcl-1 protein in myeloma cells is associated with relapse and short event-free survival in multiple myeloma patients. Recent studies show that MCL-1 is upregulated in numerous haematological and solid tumour malignancies. Therefore, MCL-1 has been suggested as a potential new therapeutic target.


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