- Featured Product
- KD/KO Validated
CoraLite® Plus 488-conjugated MCL1 Monoclonal antibody
MCL1 Monoclonal Antibody for FC (Intra), IF
Host / Isotype
Mouse / IgG2b
IF, FC (Intra)
CoraLite® Plus 488 Fluorescent Dye
Cat no : CL488-66026
|Positive IF detected in
|Positive FC detected in
|IF : 1:50-1:500
|Flow Cytometry (FC)
|FC : 0.40 ug per 10^6 cells in a 100 µl suspension
|It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
|Sample-dependent, check data in validation data gallery
The immunogen of CL488-66026 is MCL1 Fusion Protein expressed in E. coli.
|Host / Isotype
|Mouse / IgG2b
|MCL1 fusion protein Ag10609
|myeloid cell leukemia sequence 1 (BCL2-related)
|Calculated molecular weight
|350 aa, 37 kDa
|GenBank accession number
|Gene ID (NCBI)
|CoraLite® Plus 488 Fluorescent Dye
|Excitation/Emission maxima wavelengths
|493 nm / 522 nm
|Protein A purification
|PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
|Store at -20°C. Avoid exposure to light. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.
MCL-1 is an anti-apoptotic member of the Bcl-2 family originally isolated from the ML-1 human myeloid leukemia cell line. Similar to BCL2 and BCL2L1, MCL1 can interact with BAX and/or BAK1 to inhibit mitochondria-mediated apoptosis. Mcl-1 is critical for the proliferation and survival of myeloma cells in vitro, and overexpression of Mcl-1 protein in myeloma cells is associated with relapse and short event-free survival in multiple myeloma patients. Recent studies show that MCL-1 is upregulated in numerous haematological and solid tumour malignancies. Therefore, MCL-1 has been suggested as a potential new therapeutic target.