MMP10 Polyclonal antibody
MMP10 Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse
Applications
ELISA
Conjugate
Unconjugated
Cat no : 55340-1-AP
Synonyms
Validation Data Gallery
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
55340-1-AP targets MMP10 in ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide |
| Full Name | matrix metallopeptidase 10 (stromelysin 2) |
| Calculated Molecular Weight | 54 kDa |
| Observed Molecular Weight | 52 kDa |
| GenBank Accession Number | NM_002425 |
| Gene Symbol | MMP10 |
| Gene ID (NCBI) | 4319 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
MMP10, also named as STMY2, Transin-2, MMP-10, SL-2 and Stromelysin-2, belongs to the peptidase M10A family. It can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. MMP10 activates procollagenase.Western blot against MMP-10 revealed bands at a molecular weight of about 56 and 42 kDa in serum samples,and the bands with molecular weights of about 42 kDa may be the active forms of MMP-10(PMID:20215736). The expression profile of MMP-10 in several human tumors, coupled with broadsubstrate specificity and expression in several stages of the tumorigenic process suggests MMP-10 as a potential tumor marker and a predictor of clinical behavior, and supports MMP-10 inhibition as a valid therapeutic strategy(PMID:15720804).This antibody is specific to MMP10.
