MPDZ/MUPP1 Recombinant monoclonal antibody, PBS Only

• 

  WB analysis using 87358-1-RR (same clone as 87358-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 87358-1-RR (MPDZ/MUPP1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87358-1-PBS in a different storage buffer formulation.

• 

  WB analysis of SH-SY5Y using 87358-1-RR (same clone as 87358-1-PBS)

  SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 87358-1-RR (MPDZ/MUPP1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87358-1-PBS in a different storage buffer formulation.

• 

  Affinity of 87358-1-RR

  Biolayer interferometry (BLl) kinetic assays of 87358-1-RR against Human MPDZ/MUPP1 were performed. The affinity constant is 0.845 nM.

MPDZ/MUPP1 Uni-rAb^® Recombinant Antibody for WB, Indirect ELISA

Cat No. 87358-1-PBS

Clone No.252585G2

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

MPDZ, MUPP1

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Product Information

87358-1-PBS targets MPDZ/MUPP1 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Eg5584

  Product name: Recombinant human MPDZ/MUPP1 protein

  Source: mammalian cells-derived, V37

  Tag: C-rFc

  Domain: 1620-2070 aa of NM_001330637.1

  Sequence: CPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKCSLGTVTLEVGRIKAGPFHSERRPSQSSQVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVLS

• Full Name: multiple PDZ domain protein
• Calculated Molecular Weight: 222 kDa
• Observed Molecular Weight: 250-280 kDa
• GenBank Accession Number: NM_001330637.1
• Gene Symbol: MPDZ
• Gene ID (NCBI): 8777
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: O75970-1
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

The PDZ domain is a protein motif that mediates protein-protein interactions. MUPP1(multi-PDZ domain protein-1) has 13 PDZ domains, each containing the structural characteristics of a prototypic PDZ motif, but lacks a catalytic domain. MUPP1 belongs to the PDZ domain protein family and is a structural homologant of PATJ (PALS1-associated tight-linking protein) (PMID: 23880463). MUPP1 is a scaffold protein and plays an important role in cytoskeletal organization, cell polarity, and cell proliferation(PMID: 25662616). Mutations in MUPP1 are associated with congenital hydrocephalus(PMID: 23240096).