c-MYC Antibody 46 Publications

Rabbit Polyclonal| Catalog number: 10828-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 43 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Raji cells, HL-60 cells, human placenta tissue, mouse embryo tissue

Positive IP detected in:
HL-60 cells

Positive IHC detected in:
human prostate cancer tissue, mouse embryo tissue

Positive IF detected in:
NCCIT cell

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
v-myc myelocytomatosis viral oncogene homolog (avian)

Calculated molecular weight:
49 kDa

Observed molecular weight:
62-65 kDa, 50 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MYC

Synonyms
bHLHe39, c Myc, c-Myc, MRTL, MYC, Myc proto oncogene protein, Proto oncogene c Myc, Transcription factor p64
Background

MYC contains one basic helix-loop-helix (bHLH) domain. This protein is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. It seems to activate the transcription of growth-related genes. It binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. This antibody is a rabbit polyclonal antibody raised against recombinant protein of human MYC. The 50kDa band recognized by antibody is the native form of MYC, while the other bands, between 60-70kDa, are the phosphorylated form of MYC [PMID: 12189186].


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