Recombinant Mouse RANK/TNFRSF11A protein (rFc Tag)
Species
Mouse
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg1829
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Mouse RANK protein Val31-Ser214 (Accession# O35305) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 21934 |
| Accession | O35305 |
| PredictedSize | 46.3 kDa |
| SDS-PAGE | 50-65 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
RANK (TNFRSF11A)is aTNF receptor family memberthat mediatesRANKL-dependent activation of NF-κB signaling, drivingosteoclast differentiation and bone resorption. Beyond skeletal biology, RANK regulatesimmune cell functionandmammary gland development. Genetic or pathological dysregulation of the RANK–RANKL–OPG axis underliesbone metabolic disorders,inflammatory osteolysis, andcancer-associated bone disease, positioning RANK as a central therapeutic target inbone and immune regulation.
References:
1. Zhang, Dong et al. Allergy, asthma & immunology research vol. 16,4 (2024): 399-421. 2. Xue, Jing-Yi et al. Journal of human genetics vol. 66,4 (2021): 371-377. 3. Paolino, Magdalena et al. Nature vol. 589,7842 (2021): 442-447.