MultiProTM 5CFLX Anti-Human Drebrin (1A12H1)

Drebrin Monoclonal Antibody for

Host / Isotype

Mouse / IgG2a

Reactivity

Human

Applications

Conjugate

5CFLX

CloneNo.

1A12H1

Cat no : G67589-1-5C

Synonyms

D0S117E, DBN1, DKFZp434D064, Drebrin, drebrin 1

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Validation Data Gallery

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  Single Cell Sequencing experiment G67589-1-5C on Resting PBMC

  G67589-1-5C was used to stain Resting PBMC and analyzed with 10x Genomics Gene Expression Flex with Feature Barcodes and Multiplexing kit with Fix-Stain protocol.

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  Single Cell Sequencing experiment G67589-1-5C on PBMC treated with 4hr LPS + TI

  G67589-1-5C was used to stain PBMC under 4hr LPS + TI treatment and analyzed with 10x Genomics Gene Expression Flex with Feature Barcodes and Multiplexing kit with Fix-Stain protocol.

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Tested Applications

• Positive Single Cell (Intra) detected in: 10x Genomics Gene Expression Flex with Feature Barcodes and Multiplexing product.

Recommended dilution

• SINGLE CELL (INTRA): <0.5ug/test

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

G67589-1-5C targets Drebrin in applications and shows reactivity with Human samples.

• Tested Reactivity: Human
• Host / Isotype: Mouse / IgG2a
• Class: Oligo Conjugate
• Type: Monoclonal
• Immunogen: Drebrin fusion protein Ag22635
• Full Name: MultiPro^TM 5CFLX Anti-Human Drebrin (1A12H1)
• GenBank Accession Number: BC007567
• Gene Symbol: DBN1
• Gene ID (NCBI): 1627
• Conjugate: 5CFLX
• Form: Liquid
• Storage Buffer: PBS with 1mM EDTA and 0.09% sodium azide
• Storage Conditions: 2-8°C

Background Information

Drebrin (DBN1) is an actin binding and stabilizing protein with roles in endocytosis, formation of dendrite spines in neurons and coordinating cell-cell synapses in immune cells. Preferentially expressed in the brain, it is highly localized in dendritic spines and regulates spine shapes. It has two isoforms that are splice variants, with drebrin A being expressed in neural cells, and drebrin E is present in several other cell types. Recently it has been reported that circulating DBN1 levels correlated with retinal nerve fiber layer defect and may reflect the severity of retinal ganglion cells injury in glaucoma patients.