Napsin A Monoclonal antibody

Napsin A Monoclonal Antibody for ELISA

Host / Isotype

Mouse / IgG1

Reactivity

human, rat , mouse

Applications

IHC,ELISA

Conjugate

Unconjugated

CloneNo.

2D12A2

Cat no : 60259-1-Ig

Synonyms

Asp 4, ASP4, Aspartyl protease 4, KAP, Kdap, NAP1, NAPA, NAPSA, Napsin 1, Napsin A, napsin A aspartic peptidase, Pronapsin A, SNAPA, TA01/TA02



Tested Applications

Planning an IF experiment? We recommend our CoraLite®488 conjugated versions of this antibody.

Recommended dilution

ApplicationDilution
Sample-dependent, check data in validation data gallery

Published Applications

IHCSee 1 publications below

Product Information

The immunogen of 60259-1-Ig is Napsin A Fusion Protein expressed in E. coli.

Tested Reactivity human, rat , mouse
Cited Reactivity human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen Napsin A fusion protein Ag9721
Full Name napsin A aspartic peptidase
Calculated molecular weight 420 aa, 45 kDa
Observed molecular weight 45 kDa
GenBank accession numberBC017842
Gene symbol NAPSA
Gene ID (NCBI) 9476
Conjugate Unconjugated
Form Liquid
Purification Method Protein A purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Napsin is found in two isoforms, napsin A and B, with highly homologous nucleotide sequences (91.2%). Napsin A appears to be a functional proteinase, predominantly expressed in lung and kidney. Napsin B is transcribed exclusively in cells related to the immune system and lacks an in-frame stop codon and is believed to be a pseudogene.(PMID:12698189). Napsin A is superior to TTF-1 in distinguishing primary lung ACA from other carcinomas (except kidney), particularly primary lung small cell carcinoma, and primary thyroid carcinoma.(PMID:22288963).

Publications

SpeciesApplicationTitle
humanIHC

Oncotarget

Accelerated hepatocellular carcinoma development in CUL4B transgenic mice.

Authors - Jupeng Yuan