Validation Data Gallery
|Sample-dependent, check data in validation data gallery|
The immunogen of 60259-1-Ig is Napsin A Fusion Protein expressed in E. coli.
|Tested Reactivity||human, rat , mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Napsin A fusion protein Ag9721|
|Full Name||napsin A aspartic peptidase|
|Calculated molecular weight||420 aa, 45 kDa|
|Observed molecular weight||45 kDa|
|GenBank accession number||BC017842|
|Gene ID (NCBI)||9476|
|Purification Method||Protein A purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
Napsin is found in two isoforms, napsin A and B, with highly homologous nucleotide sequences (91.2%). Napsin A appears to be a functional proteinase, predominantly expressed in lung and kidney. Napsin B is transcribed exclusively in cells related to the immune system and lacks an in-frame stop codon and is believed to be a pseudogene.(PMID:12698189). Napsin A is superior to TTF-1 in distinguishing primary lung ACA from other carcinomas (except kidney), particularly primary lung small cell carcinoma, and primary thyroid carcinoma.(PMID:22288963).