|Positive WB detected in||Jurkat cells, HT-29 cells, Daudi cells, Ramos cells|
|Western Blot (WB)||WB : 1:5000-1:50000|
|Sample-dependent, check data in validation data gallery|
66878-1-Ig targets NR4A2 in WB applications and shows reactivity with Human, mouse samples.
|Tested Reactivity||Human, mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||NR4A2 fusion protein Ag1418|
|Full Name||nuclear receptor subfamily 4, group A, member 2|
|Calculated molecular weight||66 kDa|
|Observed molecular weight||67 kDa|
|GenBank accession number||BC009288|
|Gene ID (NCBI)||4929|
|Purification Method||Protein A purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
NR4A2 belongs to the orphan nuclear receptor (NR) family referred to as NR4A family, which have been implicated in cell cycle regulation, apoptosis, inflammation, metabolism and more recently in carcinogenesis [PMID:22583411]. NR4A2 also has a role in the expression of several proteins that are necessary for the synthesis and regulation of DA, such as tyrosine hidroxilase, DA transporter, vesicular monoamine transporter 2, and cRET [PMID:22294735]. Act as a transcriptional regulator, NR4A2 is essential for the differentiation and maintenance of meso-diencephalic mdDA neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons [PMID: 17184956].