NeutraKine® IL-10 Monoclonal antibody

NeutraKine® IL-10 Monoclonal Antibody for IHC, Neutralization,ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human and More (1)

Applications

Neutralization, IHC,ELISA

Conjugate

Unconjugated

CloneNo.

1E4F5

Cat no : 69018-1-Ig

Synonyms

CSIF, IL 10, IL10, IL-10, IL10A, interleukin 10, TGIF



Tested Applications

Neutralization

Published Applications

IHCSee 1 publications below

Product Information

69018-1-Ig targets NeutraKine® IL-10 in Neutralization, IHC,ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Cited Reactivity mouse
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen human NeutraKine® IL-10 protein HZ-1145
Full Name interleukin 10
Gene symbol IL10
Gene ID (NCBI) 3586
Conjugate Unconjugated
Form Lyophilized Powder
Purification Method Protein G purification
Storage Buffer Sterile PBS.
Endotoxin<0.1 EU/μg
ReconstitutionThis product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
Stability and StorageLyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

Background Information

Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

This antibody is used to Block/Neutralize IL-10 protein.

Protocols

Product Specific Protocols
Neutralization protocol of NeutraKine® IL-10 antibody 69018-1-IgDownload protocol
IHC protocol for NeutraKine® IL-10 antibody 69018-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseIHC

Int J Biol Sci

NEK2 plays an active role in Tumorigenesis and Tumor Microenvironment in Non-Small Cell Lung Cancer.

Authors - Rui Bai