OGDHL Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 17110-1-AP

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Freight/Packing

Con: 28 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse kidney tissue, mouse brain tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human brain tissue

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
oxoglutarate dehydrogenase-like

Calculated molecular weight:
1010aa,115 kDa

Observed molecular weight:
115 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
OGDHL

Synonyms
KIAA1290, OGDC E1 like, OGDHL
Background

OGDHL(oxoglutarate dehydrogenase-like) is also named as KGDE1KL, FLJ10851, KIAA1290 and belongs to the alpha-ketoglutarate dehydrogenase family. OGDHL is one of the rate-limiting component of the multienzyme OGDH complex (OGDHC) whose malfunction is associated with neuro-degeneration and it is localized only in the mitochondrial fraction and not in the cytosolic or nuclear fractions(PMID:23152800). OGDHL negatively regulates cell proliferation by inducing apoptosis in cervical cancer cells. It may thus participate in brain-specific control of 2-oxoglutarate distribution between energy production and synthesis of the neurotransmitter glutamate(PMID:18783430). It has 3 isoforms(114 kDa, 108 kDa, 91 kDa) produced by alternative splicing.


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