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PDCD5 Antibody 9 Publications

Rabbit Polyclonal| Catalog number: 12456-1-AP

Featured Product KD/KO validated

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Con: 60 μg/150 μl

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Tested Applications

Applications:
WB, IP, IHC, IF, ELISA
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Images See all

PDCD5 Antibody WB human heart tissue 12456-1-AP

human heart tissue were subjected to SDS PAGE followed by western blot with 12456-1-AP(PDCD5 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours

PDCD5 Antibody IHC human endometrial cancer tissue 12456-1-AP

Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissue slide using 12456-1-AP (PDCD5 antibody) at dilution of 1:200 (under 10x lens) heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

PDCD5 Antibody IHC human endometrial cancer tissue 12456-1-AP

Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissue slide using 12456-1-AP (PDCD5 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

Species specificity:
human
Positive WB detected in:
human heart tissue, PC-3 cells, human brain tissue, A549 cells
Positive IHC detected in:
human endometrial cancer tissue, human skin cancer tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:500
Sample-dependent, check data in Validation tab

Protocols

Product-specific protocols

Standard Protocols

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
PDCD5 fusion protein Ag3122
Full name:
programmed cell death 5
Calculated molecular weight:
125aa,14 kDa
Observed molecular weight:
14 kDa
GenBank accession number:
BC015519
Gene ID (NCBI):
9141
Gene symbol
PDCD5
Synonyms
PDCD5, programmed cell death 5, Protein TFAR19, TFAR19

Background

PDCD5, also called TFAR19 (TF1 cell apoptosis-related gene 19), was first identified as a gene up-regulated in TF-1 cells under-going apoptosis (PMID: 9920759). PDCD5 can promote pro-grammed cell death in different cell types in response to various stimuli and also enhance TAJ/TROY-induced paraptosis-like cell death (PMID: 15020679). During apoptosis, PDCD5 is rapidly upregulated and translocates from the cytoplasm to nucleus (PMID: 11741587). PDCD5 is a positive regulator of Tip60 and also has a potential ability to interact with p53 (PMID: 22914926, PMID: 19308289). Recent studies have also revealed that PDCD5 may be a suppressor gene and expressed at lower levels in many cancers, including hepatocellular carcinoma, breast cancer, gastric cancer, cervical cancer, lung cancer, astrocytic gliomas, and in leukemia.


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