PINK1 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 23274-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 30 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HeLa cells,mouse liver tissue, Jurkat cells

Positive IHC detected in:
human brain tissue

Positive IF detected in:
mouse brain tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen Affinity purified

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
PTEN induced putative kinase 1

Calculated molecular weight:
581aa,63 kDa

Observed molecular weight:
65 kDa, 45 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PINK1

Synonyms
BRPK, FLJ27236, PARK6, PINK1, PTEN induced putative kinase 1
Background

PINK1 is a mitochondrial serine/threonine-protein kinase that protects cells from stress-induced mitochondrial dysfunction. The precursor of PINK1 (65 kDa) is synthesized in the cytosol and is imported into the outer membrane of mitochondria. PINK1 is further transferred into the inner membrane where it is cleaved into a 52 kDa mature form. The half life of the mature form of PINK1 is very short and it was proposed that the proteasome is involved in its degradation (PMID: 23472196). The gene of PINK1 maps to chromosome 1p36.12. Two alternatively spliced variants exist, the shorter isoform (30 kDa) produced by alternative splicing. Mutations in the PINK1 gene cause autosomal recessive early-onset Parkinson's disease.


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