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CoraLite® Plus 488-conjugated PINK1 Polyclonal antibody

PINK1 Polyclonal Antibody for IF

Host / Isotype

Rabbit / IgG


human, mouse, rat




CoraLite® Plus 488 Fluorescent Dye

Cat no : CL488-23274


BRPK, FLJ27236, PARK6, PINK1, PTEN induced putative kinase 1

Tested Applications

Positive IF detected inmouse brain tissue

Recommended dilution

Immunofluorescence (IF)IF : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

CL488-23274 targets PINK1 in IF applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen PINK1 fusion protein Ag19825
Full Name PTEN induced putative kinase 1
Calculated Molecular Weight 581 aa, 63 kDa
Observed Molecular Weight 65 kDa, 45 kDa
GenBank Accession NumberBC028215
Gene Symbol PINK1
Gene ID (NCBI) 65018
Conjugate CoraLite® Plus 488 Fluorescent Dye
Excitation/Emission Maxima Wavelengths493 nm / 522 nm
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

PINK1 is a mitochondrial serine/threonine-protein kinase that protects cells from stress-induced mitochondrial dysfunction. The precursor of PINK1 (65 kDa) is synthesized in the cytosol and is imported into the outer membrane of mitochondria. PINK1 is further transferred into the inner membrane. The full-length PINK1 can be proteolytically processed into 52-55 kDa and 45-46 kDa forms (PMID: 18221368; 25108683; 18031932). The half life of the mature form of PINK1 is very short and it was proposed that the proteasome is involved in its degradation (PMID: 23472196). The gene of PINK1 maps to chromosome 1p36.12. Two alternatively spliced variants exist, the shorter isoform (30 kDa) produced by alternative splicing. Mutations in the PINK1 gene cause autosomal recessive early-onset Parkinson's disease.


Product Specific Protocols
IF protocol for CL Plus 488 PINK1 antibody CL488-23274Download protocol
Standard Protocols
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