SHANK1 Polyclonal antibody

SHANK1 Polyclonal Antibody for WB,ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB,ELISA

Conjugate

Unconjugated

Cat no : 55059-1-AP

Synonyms

SHANK1, SPANK 1, SSTR interacting protein, SSTRIP, synamon



Tested Applications

Positive WB detected inhuman brain tissue

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:200-1:1000
Sample-dependent, check data in validation data gallery

Published Applications

WBSee 2 publications below

Product Information

55059-1-AP targets SHANK1 in WB,ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivity mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name SH3 and multiple ankyrin repeat domains 1
Calculated molecular weight 225 kDa
Observed molecular weight 250-300 kDa
GenBank accession numberNM_016148
Gene symbol SHANK1
Gene ID (NCBI) 50944
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Aliquoting is unnecessary for -20oC storage.

Background Information

SHANK1 belongs to the SHANK family. It seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. SHANK1 may play a role in the structural and functional organization of the dendritic spine and synaptic junction. The antibody is specific to SHANK1.

Protocols

Product Specific Protocols
WB protocol for SHANK1 antibody 55059-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
ratWB

Neural Regen Res

Protective effects of Bushen Tiansui decoction on hippocampal synapses in a rat model of Alzheimer's disease.

Authors - Shan Hui
mouseWB

Cell Res

METTL3-mediated N6-methyladenosine mRNA modification enhances long-term memory consolidation.

Authors - Zeyu Zhang