STAT3 Antibody 23 Publications

Rabbit Polyclonal| Catalog number: 10253-2-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 44 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells,mouse brain tissue, A549 cells, mouse heart tissue, Jurkat cells, K-562 cells, rat brain tissue, MCF-7 cells, NIH/3T3 cells, mouse lung tissue, A431 cells, mouse thymus tissue

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human cervical cancer tissue, human breast cancer tissue, human cervical cancer tissue

Positive IF detected in:
HeLa cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:1000-1:4000 for WB
IHC : 1:50-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
signal transducer and activator of transcription 3 (acute-phase response factor)

Calculated molecular weight:
770aa,88 kDa

Observed molecular weight:
88 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
STAT3

Synonyms
Acute phase response factor, APRF, FLJ20882, HIES, STAT3
Background

Signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3, synonyms: APRF, FLJ20882, MGC16063) is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT3 is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of STAT3. This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human STAT3. STAT3 exists three isoforms and the molecular weight of each isoform respectively is 83 kDa, 87 kDa and 88 kDa.


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