transgelin/SM22 Antibody 26 Publications

Rabbit Polyclonal| Catalog number: 10493-1-AP

Featured Product KD/KO validated

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Con: 34 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse colon tissue, Caco-2 cells, human colon tissue

Positive IHC detected in:
human heart tissue, human colon cancer tissue, human heart tissue

Positive IF detected in:
mouse heart tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
transgelin

Calculated molecular weight:
22 kDa

Observed molecular weight:
19-22 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TAGLN

Synonyms
SM22, SM22 alpha, SM22a, SM22alpha, TAGLN, TAGLN1, transgelin
Background

The transgelin family is a group of proteins that belong to 22kd actin-related calponin superfamily. Of all three isoforms, transgelin 1 is the best characterized. Transgelin 1, also known as SM22alpha, is a specific marker for differentiated smooth muscle cells. Transgelin 2, also known as SM22 beta, is expressed by both smooth muscle and non-smooth muscle cells in a temporally and spatially regulated pattern. Trangenlin 3, also known as NP25, is only found in highly differentiated neuronal cells. This antibody was generated against full length transgelin 1 protein. It can cross-react with other two transgelins based on the sequence similarity.


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