NeutraKine™ TGF beta 1 Monoclonal antibody

NeutraKine™ TGF beta 1 Monoclonal Antibody for FC, Neutralization,ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

Neutralization, FC,ELISA

Conjugate

Unconjugated

CloneNo.

1E3E9

Cat no : 69012-1-Ig

Synonyms

CED, DPD1, LAP, TGF ?1, TGF beta 1, TGFB, TGFB1, TGFbeta, TGF-beta1



Tested Applications

Planning an IF experiment? We recommend our CoraLite®647 conjugated versions of this antibody.
Neutralization

Product Information

69012-1-Ig targets NeutraKine™ TGF beta 1 in Neutralization, FC,ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen human Humankine TGF beta 1 protein HZ-1011
Full Name transforming growth factor, beta 1
Gene symbol TGFB1
Gene ID (NCBI) 7040
Conjugate Unconjugated
Form Lyophilized Powder
Purification Method Protein G purification
Storage Buffer Sterile PBS.
Endotoxin<0.1 EU/μg
ReconstitutionThis product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
Stability and StorageLyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

Background Information

TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. It is highly expressed in bone. Mutation of TGFB are the cause of Camurati-Engelmann disease (CED) which known as progressive diaphyseal dysplasia 1 (DPD1).

This antibody is used to Block/Neutralize TGF beta 1 protein.

Protocols

Product Specific Protocols
Neutralization protocol of NeutraKine™ TGF beta 1 antibody 69012-1-IgDownload protocol
FC protocol for NeutraKine™ TGF beta 1 antibody 69012-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols