CoraLite®647-conjugated TGF beta 1 Monoclonal antibody
TGF beta 1 Monoclonal Antibody for FC (Intra)
Host / Isotype
Mouse / IgG1
CoraLite®647 Fluorescent Dye
Cat no : CL647-69012
|Positive FC detected in||HEK-293 cells|
|Sample-dependent, check data in validation data gallery|
CL647-69012 targets TGF beta 1 in FC (Intra) applications and shows reactivity with Human samples.
|Host / Isotype||Mouse / IgG1|
|Immunogen||TGF beta 1 fusion protein HZ-1011|
|Full Name||transforming growth factor, beta 1|
|Gene ID (NCBI)||7040|
|Conjugate||CoraLite®647 Fluorescent Dye|
|Excitation/Emission maxima wavelengths||650 nm/665 nm|
|Purification Method||Protein G purification|
|Storage Buffer||PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.|
|Storage Conditions||Store at -20°C. Avoid exposure to light. Aliquoting is unnecessary for -20oC storage.|
TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. It is highly expressed in bone. Mutation of TGFB are the cause of Camurati-Engelmann disease (CED) which known as progressive diaphyseal dysplasia 1 (DPD1).
This antibody is used to Block/Neutralize TGF beta 1 protein.