• HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human TGF beta 1 protein

Activity

Typically ≤ 0.5 ng/mL EC50

Species Reactivity

human,mouse

Purity

>95%

Cat no : HZ-1011

Synonyms

CED, DPD1, LAP, TGF B1, TGF beta 1, tgf beta1, TGFB, TGFB1, TGFbeta, tgf-beta1



Technical Specifications

GeneID 7040
Species Human
Expression HEK293
Activity Typically ≤ 0.5 ng/mL EC50
Purity >95%
Endotoxin<1 EU/µg
Accession NumberP01137
Molecular Mass 25 kDa, homodimer, nonglycosylated
Formulation 50 mM NaOAc pH 3.7, See Certificate of Analysis for details
Species Reactivity human,mouse

Stability and Reconstitution

Stability and StorageProduct FormTemperature ConditionsStorage Time
(From Date of Receipt)
Lyophilized-20°C to -80°CUntil Expiry Date
LyophilizedRoom Temperature2 weeks
Reconstituted as per CofA-20°C to -80°C6 months
Reconstituted as per CofA4°C1 week
Avoid repeated freeze-thaw cycles.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Background

TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, and cell differentiation. TGF acts synergistically with TGFA in inducing transformation process. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB having specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling being a potent stimulator of an osteoblastic bone formation (PMID: 11586292).

Synonyms

CED, DPD1, LAP, TGF B1, TGF beta 1, tgf beta1, TGFB, TGFB1, TGFbeta, tgf-beta1

Publications

SpeciesTitle
human

Nature

Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia.

Authors - Lucia M Moreira
human

Nat Biotechnol

Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells.

Authors - DeepaSubramanyam
human

Nat Cell Biol

A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1.

Authors - Ji-Hyung Lee
mouse

Nat Commun

Smad6 inhibits non-canonical TGF-β1 signalling by recruiting the deubiquitinase A20 to TRAF6.

Authors - Su MyungJung
human

Nat Commun

Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs.

Authors - Guang-HuiLiu
human

Nat Commun

PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype.

Authors - ShunleiDuan