Product Information
CL647-66498 targets TRAF6 in WB applications and shows reactivity with Human samples.
| Tested Reactivity | Human |
| Cited Reactivity | human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag24696 Product name: Recombinant human TRAF6 protein Source: e coli.-derived, PET30a Tag: 6*His Domain: 1-274 aa of BC031052 Sequence: MSLLNCENSCGFSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILKDCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLA Predict reactive species |
| Full Name | TNF receptor-associated factor 6 |
| Calculated Molecular Weight | 522 aa, 60 kDa |
| Observed Molecular Weight | 60 kDa |
| GenBank Accession Number | BC031052 |
| Gene Symbol | TRAF6 |
| Gene ID (NCBI) | 7189 |
| Conjugate | CoraLite® Plus 647 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 654 nm / 674 nm |
| Excitation Laser | Red Laser (633 nm) |
| Form | Liquid |
| Purification Method | Protein G purification |
| UNIPROT ID | Q9Y4K3 |
| Storage Buffer | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
TRAF6 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF6 is recognized as a signal transducer, which activates the NF-κB pathway in response to pro-inflammatory cytokines. TRAF6 has E3 ligase activity and is responsible for inducing Lys-63 (K63)-linked poly-ubiquitination chains, functioning together with E2 Ubc13/Uev1A complex to mediate IKK activation TRAF6 plays a crucial role in the regulation of the innate and adaptive immune responses.
Publications
What published studies show
The TRAF6 Monoclonal antibody (clone 1D1E1), catalog number CL647-66498, has a total of 1 citation. It appears in the journal Balkan Medical Journal (2023). The cited study investigated how asiaticoside down-regulates HIF-1α to inhibit proliferation, migration, and angiogenesis in thyroid cancer cells, placing this citation in the research fields of thyroid cancer biology, hypoxia signaling, and tumor angiogenesis. The antibody was used in Western blot applications on human samples.
| Species | Application | Title |
|---|---|---|
Balkan Med J Asiaticoside Down-Regulates HIF-1α to Inhibit Proliferation, Migration, and Angiogenesis in Thyroid Cancer Cells |
