TTYH3 Polyclonal antibody

TTYH3 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 24707-1-AP

Synonyms

hTTY3, KIAA1691, Protein tweety homolog 3, TTYH3, tweety homolog 3 (Drosophila)

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Validation Data Gallery

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  WB analysis using 24707-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 24707-1-AP (TTYH3 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: HeLa cells, U2OS cells

Recommended dilution

• Western Blot (WB): WB : 1:2000-1:10000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

24707-1-AP targets TTYH3 in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: TTYH3 fusion protein Ag18804
• Full Name: tweety homolog 3 (Drosophila)
• Calculated Molecular Weight: 523 aa, 58 kDa
• Observed Molecular Weight: 50 kDa
• GenBank Accession Number: BC131824
• Gene Symbol: TTYH3
• Gene ID (NCBI): 80727
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Tweety homologs (TTYHs) are conserved transmembrane proteins present in all eukaryotes including three members (TTYH1, TTYH2, and TTYH3) in humans. They are widely expressed in mammals including at high levels in the nervous system and have been implicated in cancers and other diseases including epilepsy, chronic pain, and viral infections. Physiologically, TTYH2 and TTYH3 are broadly expressed, while expression of TTYH1 is primarily limited to the nervous system, testes, and stem cells. TTYH3 is upregulated in gastric cancer with higher expression correlated with poor clinical outcomes. (PMID: 34824283)