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HSA: Human serum albumin’s importance in biology and biotech
Human serum albumin (HSA) is the most abundant protein in the blood and has many vital biological roles. It is a vehicle for a host of small molecules and proteins, regulates oncotic pressure, and performs the majority of antioxidation in the body. In medicine, it is broadly used for the treatment of hypovolemia, shock, burns, severe blood loss, hemorrhage, and liver disease. In biotechnology applications, it is used to enhance drug delivery and in maintaining cell culture (1).
The demand for HSA exceeds 500 tons (1). Currently, the majority is collected from humans, but yields are low, and there are risks of infectious agent transmission. There have been efforts to create recombinant sources, including mice (2), cows (3), and rice (4). However, international regulations are pushing xenobiotic and animal component-free production to ensure safety for human use (1). Besides adhering to these rules,Humankine HSA is scalable for GMP production, making it ideal for industrial applications.
Proteintech’s Humankine® HSA is made from HEK293 human cells, conferring authentic glycosylation and folding in addition to superior stability and activity.
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Humankine® products are created in HEK293 cells using animal-free components. Our human expression system ensures that proteins have native conformation and post-translational modifications to optimize biological activity.