HSA: Human serum albumin

Human serum albumin’s (HSA) importance in biology and biotech

Human serum albumin (HSA) is the most abundant protein in the blood and has many vital biological roles. It is a vehicle for a host of small molecules and proteins, regulates oncotic pressure, and performs the majority of antioxidation in the body. In medicine, it is broadly used for the treatment of hypovolemia, shock, burns, severe blood loss, hemorrhage, and liver disease. In biotechnology applications, it is used to enhance drug delivery and in maintaining cell culture (1).

The demand for HSA exceeds 500 tons (1). Currently, the majority is collected from humans, but yields are low, and there are risks of infectious agent transmission. There have been efforts to create recombinant sources, including mice (2), cows (3), and rice (4). However, international regulations are pushing xenobiotic and animal component-free production to ensure safety for human use (1). Besides adhering to these rules,Humankine HSA is scalable for GMP production, making it ideal for industrial applications.


Proteintech’s Humankine® HSA

Proteintech’s Humankine® HSA is made from HEK293 human cells, conferring authentic glycosylation and folding in addition to superior stability and activity.

Product name Catalog number ED50 Purity
Recombinant human HSA protein HZ-3001 N/A >95%


HumanKine recombinant proteins 



  1. Human Serum Albumin: From bench to bedside

  2. The extremely high-level expression of human serum albumin in the milk of transgenic mice

  3. TALEN-Mediated Modification of the Bovine Genome for Large-Scale Production of Human Serum Albumin

  4. Expression and purification of recombinant human serum albumin from selectively terminable transgenic rice