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  • HEK293 expressed
  • Endotoxin-free
  • Animal-component free

GMP grade Animal-free Recombinant Human PDGFbb

EC50

0.5-3 ng/mL

Specific Activity

2,000,000-333,000 Units/mg

Species Reactivity

human

Purity

>95%

ISO 13485 certified HumanKine® human cell-expressed cytokines and growth factors

Cat no : HZ-1308-GMP

Synonyms

Becaplermin, c sis, FLJ12858, PDGF 2, PDGF subunit B, PDGF2, PDGFB, PDGFbb, Proto oncogene c Sis, SIS, SSV



Technical Specifications

GeneID 5155
Species human
Expression HEK293
EC50 0.5-3 ng/mL
Specific Activity2,000,000-333,000 Units/mg
Purity >95%
Molecular Mass 29 to 32 kDa, homodimer, glycosylated
Formulation 50mM Acetate pH 3.5 + 500mM NaCl, See Certificate of Analysis for details
Species Reactivity human, mouse

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20oC) and (-80oC). Upon reconstitution we recommend that the solution can be stored at (4oC) for short term or at (-20oC) to (-80oC) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 10 mM HOAc containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

GMP Quality Policies

HumanKine® GMP (Good Manufacturing Practice) recombinant proteins are manufactured and validated in accordance with ISO 13485 quality management system and is compliant with GMP.
Our GMP recombinant proteins are animal component free (ACF), xeno free (XF) and tag free (TF). Read more about these policies here.

Product Description

Animal-free Recombinant Human PDGFbb is a growth factor that promotes blood vessel formation, mitogenesis, chemotaxis, etc. The PDGF family members (four homodimers and one heterodimer) are secreted, disulfide-linked dimeric glycoproteins that regulate their cellular functions through interaction with PDGFR receptors. PDGFbb is synthesized, stored, and released by alpha granules of platelets. It is also known as PDGF-2, becaplermin, or GDGF. Dysregulation in PDGF signaling has been shown to be associated with tumorigenesis and progression of cancer. Recombinant PDGFbb is used in treatment of chronic ulcers and to speed healing in surgical procedures.

Synonyms

Becaplermin, c sis, FLJ12858, PDGF 2, PDGF subunit B, PDGF2, PDGFB, PDGFbb, Proto oncogene c Sis, SIS, SSV