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  • HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human IFN gamma protein

Activity

Typically ≤ 0.05 ng/mL EC50

Species Reactivity

human

Purity

>95%

Cat no : HZ-1301

Synonyms

IFG, IFI, IFN gamma, IFNG, Immune interferon, Interferon gamma, interferon, gamma



Technical Specifications

GeneID 3458
Species human
Expression HEK293
Activity Typically ≤ 0.05 ng/mL EC50
Purity >95%
Molecular Mass 29-32 kDa
Formulation 1x PBS, See Certificate of Analysis for details
Species Reactivity human

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1x PBS containing 0.1% endotoxin-free recombinant human albumin (HSA).

Background

Interferon gamma (IFN γ), is a type II interferon that provides immunity against bacterial, viral and protozoan infections. In its active form, IFN γ is a glycosylated, non-covalently linked homodimer of 29-32 kDa subunits. It is produced by a number of immune cell types including natural killer cells, natural killer T cells, and effector lymphocyte T cells following antigenic and inflammatory triggers. The IFN γ dimer binds to its cognate receptor which has two subunits: IFN-γR1 which is the ligand-binding chain (α chain) and IFN-γR2, the signal-transducing chain (β chain). Binding to the receptor activates the JAK/STAT pathway which in turn activates IFN γ responsive genes. While IFN γ can inhibit viral replication, it also works as an immune-modulator and immune-stimulator by increasing surface expression of class I MHC proteins (PMID: 19268625; 10688427)

Synonyms

IFG, IFI, IFN gamma, IFNG, Immune interferon, Interferon gamma, interferon, gamma

Publications

SpeciesTitle
mouse

Pharm Biol

β-Sitosterol modulates macrophage polarization and attenuates rheumatoid inflammation in mice.

Authors - Rui Liu
mouse

Cell Death Dis

Nestin protects podocyte from injury in lupus nephritis by mitophagy and oxidative stress.

Authors - Yuexin Tian
human,mouse

ArXiv

Darwin's Neural Network: AI-based Strategies for Rapid and Scalable Cell and Coronavirus Screening.

Authors - Sang Won Lee
human

Cell Rep

Critical role of Syk-dependent STAT1 activation in innate antiviral immunity.

Authors - Shasha Liu
human

Pulm Pharmacol Ther

Guanosine and uridine alleviate airway inflammation via inhibition of the MAPK and NF-κB signals in OVA-induced asthmatic mice.

Authors - Yujiao Luo
human

Int J Mol Med

IRF1 regulates the progression of colorectal cancer via interferon‑induced proteins.

Authors - Xiaohui Xu