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  • HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human pro IGF-II protein

Activity

Typically ≤ 50 ng/mL EC50

Species Reactivity

human

Purity

>95%

Cat no : HZ-1161

Synonyms

C11orf43, FLJ22066, FLJ44734, IGF II, IGF2, INSIGF, Insulin like growth factor II, pp9974, Somatomedin A



Technical Specifications

GeneID 3481
Species human
Expression HEK293
Activity Typically ≤ 50 ng/mL EC50
Purity >95%
Molecular Mass 25 kDa, monomer, glycosylated
Formulation 10 mM Tris-HCl pH 7.4 + 350 mM NaCl, See Certificate of Analysis for details
Species Reactivity human

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Background

IGF2 is a hormone involved in the regulation of cell proliferation, growth, migration, differentiation, and survival. IGF2 is mostly expressed in early embryonic and fetal development. Adult IGF2 expression occurs in the liver and epithelial cells lining the surface of the brain. IGF2 can also be detected in plasma (PMID: 24593700; 23257688)

Synonyms

C11orf43, FLJ22066, FLJ44734, IGF II, IGF2, INSIGF, Insulin like growth factor II, pp9974, Somatomedin A

Publications

SpeciesTitle
human

J Clin Endocrinol Metab

Paracrine Pathways in Uterine Leiomyoma Stem Cells Involve Insulinlike Growth Factor 2 and Insulin Receptor A.

Authors - Molly B Moravek
mouse

Stem Cells

Pro-Insulin-Like Growth Factor-II Ameliorates Age-Related Inefficient Regenerative Response by Orchestrating Self-Reinforcement Mechanism of Muscle Regeneration.

Authors - Madoka Ikemoto-Uezumi