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  • HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human Thrombopoietin protein

Activity

Typically ≤ 5 ng/mL EC50

Species Reactivity

human

Purity

>95%

Cat no : HZ-1248

Synonyms

MGDF, MKCSF, ML, MPLLG, THPO, Thrombopoietin



Technical Specifications

GeneID 7066
Species human
Expression HEK293
Activity Typically ≤ 5 ng/mL EC50
Purity >95%
Endotoxin< 1 EU/µg
Accession NumberP40225
Molecular Mass 80 to 85 kDa, monomer, glycosylated.
Formulation 1x PBS, See Certificate of Analysis for details
Species Reactivity human

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Background

Thrombopoietin (TPO) is a primary regulator of megakaryocyte development and platelet production in mammals. Human Thrombopoietin constitutively circulates and maintains thrombopoiesis through interaction with its cognate receptor, myeloproliferative leukemia protein(MPL). Thrombopoietin also plays an important role in the maintenance and regulation of hematopoietic stem cells (HSCs).

Synonyms

MGDF, MKCSF, ML, MPLLG, THPO, Thrombopoietin

Publications

SpeciesTitle
human

ACS Biomater Sci Eng

Bioprinting of Human Cord Blood-Derived CD34+ Cells and Exploration of the Multilineage Differentiation Ability in Vitro.

Authors - Lidan Chen
human

Sci Rep

A 3D engineered scaffold for hematopoietic progenitor/stem cell co-culture in vitro.

Authors - Dezhi Zhou
human

Oncotarget

Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling.

Authors - JingLi
human

J Cell Physiol

HCMV modulates c-Mpl/IEX-1 pathway-mediated megakaryo/thrombopoiesis via PDGFRα and αvβ3 receptors after allo-HSCT.

Authors - Fei-Er Feng
human

J Exp Med

Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML.

Authors - AndrewVolk