APPL1 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 12639-1-AP

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Freight/Packing

Con: 20 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human brain tissue, mouse ovary tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human ovary tumor tissue

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

Calculated molecular weight:
709aa,80 kDa

Observed molecular weight:
80kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
APPL1

Synonyms
APPL, APPL1, Dip13 alpha, DIP13A, DIP13alpha, KIAA1428
Background

Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1), a binding partner of Akt2 and an important regulator of insulin signaling, plays a key role in the regulation of insulin secretion [PMID:22615370]. APPL1 interacts with adiponectin receptors and mediates the insulin-sensitizing effects of adiponectin in muscle and endothelial cells. It also participates in nuclear signaling and transcriptional regulation, mostly by modulating the activity of various nuclear factors [PMID:22685329]. Apart from its role in endocytosis and endosomal transport, APPL1 was reported to undergo nucleocytoplasmic shuttling and participate in transcriptional regulation, e.g. by interactions with histone deacetylases (HDACs) [PMID:19686092].


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