Amphiregulin Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66433-1-Ig |CloneNo.: 1A1G9

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Freight/Packing

Con: 150 μg/150 μl

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Species specificity:
human, rat

Positive WB detected in:
A549 cells, MCF-7 cells, rat brain tissue

Positive IHC detected in:
human pancreas cancer tissue, human colon cancer tissue

Recommended dilution:
WB : 1:1000-1:6000
IHC : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
amphiregulin

Calculated molecular weight:
252aa,28 kDa

Observed molecular weight:
50 kDa, 37 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
AREG

Synonyms
amphiregulin, AR, AREG, AREGB, CRDGF, SDGF
Background

Amphiregulin (AREG) is one of the ligands of the epidermal growth factor receptor (EGFR). AREG plays a central role in mammary gland development and branching morphogenesis in organs and is expressed both in physiological and in cancerous tissues. The AREG protein is synthesized as a 252-amino acid transmembrane precursor, pro-AREG. At the plasma membrane, pro-AREG is subjected to sequential proteolytic cleavages within its ectodomain and is then released as the soluble AREG protein. Depending on the cell type and microenvironment, AREG can be produced in multiple cellular and mature forms using alternative pro-AREG cleavage sites and glycosylation motifs. Post-translastional modfications of 50-kDa pro-AREG produces a major soluble 43-kDa form, 28-, 26-, 16-kDa membrane anchored forms, and soluble 21-, 19-, and 9-kDa forms (PMID: 9642297).


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