ATG5 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 60061-1-Ig |CloneNo.: 3G6E6

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Freight/Packing

Con: 119 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
K-562 cells, HeLa cells

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Caprylic acid/ammonium sulfate precipitation

Isotype:
IgM

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ATG5 autophagy related 5 homolog (S. cerevisiae)

Calculated molecular weight:
32 kDa

Observed molecular weight:
55 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ATG5

Synonyms
APG5, APG5 LIKE, APG5L, Apoptosis specific protein, ASP, ATG5, Autophagy protein 5, hAPG5
Background

ATG5, also named as APG5L and ASP, belongs to the ATG5 family. It is required for autophagy. It plays an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of bulk cytoplasmic contents. Formation of the autophagosome involves a ubiquitin-like conjugation system in which Atg12 is covalently bound to Atg5 and targeted to autophagosome vesicles. It mediates autophagosome-independent host protection.


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