cIAP1 Antibody 9 Publications

Rabbit Polyclonal| Catalog number: 10022-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 33 μg/150 μl

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Species specificity:
human, mouse, zebrafish

Positive WB detected in:
mouse skeletal muscle tissue, Jurkat cells, mouse brain tissue, mouse liver tissue, mouse testis tissue

Positive IHC detected in:
human testis tissue, human brain tissue, human kidney tissue, human ovary tissue, human pancreas tissue, human placenta tissue, human spleen tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:50-1:500
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
baculoviral IAP repeat-containing 2

Calculated molecular weight:
618aa,70 kDa

Observed molecular weight:
70 kDa, 55-60 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BIRC2

Synonyms
API1, BIRC2, C IAP1, cIAP1, Hiap 2, HIAP2, IAP 2, IAP homolog B, IAP2, MIHB, RING finger protein 48, RNF48
Background

BIRC2 (also known as cIAP1) is a member of the inhibitor of apoptosis protein (IAP) family. The inhibitor of apoptosis (IAP) proteins are a family of anti-apoptotic regulators found in viruses and metazoans. BIRC2 is a nuclear shuttling protein, whose subcellular localization is mediated by the CRM1-dependent nuclear export pathway (PMID: 15265700). The protein is regulated transcriptionally and can be inhibited by mitochondrial proteins released in the cytoplasm upon apoptotic stimuli (PMID: 15187025). BIRC2 is also believed to be a critical regulator of vascular integrity and endothelial cell survival, thereby providing an additional target pathway for the control of angiogenesis and blood vessel homeostasis during embryogenesis, regeneration and tumorigenesis (PMID: 17934460). This BIRC2 antibody (10022-1-AP) can bind both full length (70kd) and cleaved form (60kd) of the protein.


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