Bcl-XL/S Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 26967-1-AP

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Freight/Packing

Con: 65 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
NIH/3T3 cells, RAW 264.7 cells

Positive IP detected in:
NIH/3T3 cells

Positive IHC detected in:
human testis tissue, human lung cancer tissue, human testis tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
BCL2-like 1

Calculated molecular weight:
26 kDa

Observed molecular weight:
30 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BCL2L1

Synonyms
Apoptosis regulator Bcl X, BCL2L1, Bcl-xL, DKFZp781P2092
Background

BCL2L1 is a member of he BCL-2 protein family. BCL2L1 is expressed as two distinct isoforms, Bcl-xL and Bcl-xS, and is located at the outer mitochondrial membrane. The Bcl-XL isoform is a 233 amino acid protein, acting as an apoptotic inhibitor. Bcl-XL can forms heterodimers with BAX, BAK or BCL2, and the heterodimerization with BAX does not seem to be required for anti-apoptotic activity. The Bcl-XS isoform is a shorter variant that is 178 amino acids in length and lacks a 63 amino acid region (amino acids 126-188), acting as an apoptotic activator. This antibody can recognize Bcl-XL, Bcl-XS and Bcl-X(Beta).


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